Research

Working Memory

We are interested in studying Working Memory;  the controlled processing of information available in short-term memory.  

Working memory is crucial to guide our behavior and social interaction and it is necessary for proper decision-making process. Working memory is composed of three phases: 1) the acquisition of a piece of information 2) A delay period during which the information is not available 3) An indication or cue that prompts the utilization of the information.

We study a neuronal pattern of activity observed during the delay phase of Working memory task, named persistent firing activity. 

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Mechanisms of Neuronal persistent activity in the cortex

We study basic mechanisms necessary for neurons to initiate and to terminate persistent firing activity using brain slices. 
Techniques:
- Electrophysiology
- Calcium imaging
- Behavioural studies
- Confocal microscopy

Regulation of Neuronal activity by Neurotrophins

The Gibon lab aims at understanding how neuronal environmental factors modulate persistent firing activity in the cortex. We study neurotrophin factors such as the Brain Derived Neurotrophic Factor (BDNF), the Nerve Growth Factor (NGF) and their profrom (proBDNF, proNGF). 

Techniques:

- Electrophysiology

- Calcium imaging

- Confocal microscopy

-  Immunohistochemistry

- Immunocytochemistry

- Western Blot

“The problem of neurology is to understand man himself” -Dr. Wilder Penfield